Download The Newborn Lung: Neonatology Questions and Controversies by Eduardo Bancalari PDF

By Eduardo Bancalari

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1996;128:464-469. 148. Ichiba H, Saito M, Yamano T. Amniotic fluid transforming growth factor-beta1 and the risk for the development of neonatal bronchopulmonary dysplasia. Neonatology. 2009;96:156-161. 149. Kunzmann S, Speer CP, Jobe AH, Kramer BW. Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs. Am J Physiol Lung Cell Mol Physiol. 2007;292: L223-L231. 150. Bland RD, Xu L, Ertsey R, et al. Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease.

VEGF receptor 2 blockade disrupts postnatal lung development. Am J Respir Cell Mol Biol. 2005;32:420-427. 106. Tang JR, Markham NE, Lin YJ, et al. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol. 2004;287(2):L344-L351. 107. Leuwerke SM, Kaza AK, Tribble CG, et al. Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice. Am J Physiol Lung Cell Mol Physiol.

95 IFNγ-mediated abnormal lung architecture was associated with increased cell death and upregulation of cell death pathway mediators caspases 3, 6, 8 and 9, and Ang2. 96 Interleukin-1β Backstrom and associates97 reported that conditional overexpression of human IL-1β in the saccular stage caused arrest in alveolar development and airway remodeling in a murine model; however, activation in the late canalicular–early saccular stage did not adversely affect lung development, growth, or survival of the pups.

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